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<p>Locally advanced basal cell carcinoma can be a&#xa0;difficult-to-treat disease, particularly in areas such as the face that are sensitive to mutilating surgery or radiotherapy. Hedgehog inhibitors including sonidegib that are administered orally once daily have been developed for the treatment of these patients. The case reports detailed here relate to two over 90-year-old female patients with facial basal cell carcinomas. Their advanced age, comorbidities, and tumor locations close to the eye and on the nose precluded extensive surgery or irradiation. Treatment with sonidegib 200 mg led to rapid and lasting responses, with complete or near-complete regression that eventually enabled curative surgery in one case and preservation of the right eye in the other. Side effects occurred infrequently and were managed using symptomatic therapies as well as dose modification. In addition to surgery and irradiation, sonidegib is an effective and tolerable treatment option for locally advanced basal cell carcinoma that can be expected to work in any age group.</p>

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Rapid and Deep Responses to Sonidegib Therapy in Elderly Patients With Locally Advanced Basal Cell Carcinomas: Two Case Reports

  • 期刊论文

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  • 发表日期：

    2025年1月7日

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  • Andreas Stepan

摘要

Locally advanced basal cell carcinoma can be a difficult-to-treat disease, particularly in areas such as the face that are sensitive to mutilating surgery or radiotherapy. Hedgehog inhibitors including sonidegib that are administered orally once daily have been developed for the treatment of these patients. The case reports detailed here relate to two over 90-year-old female patients with facial basal cell carcinomas. Their advanced age, comorbidities, and tumor locations close to the eye and on the nose precluded extensive surgery or irradiation. Treatment with sonidegib 200 mg led to rapid and lasting responses, with complete or near-complete regression that eventually enabled curative surgery in one case and preservation of the right eye in the other. Side effects occurred infrequently and were managed using symptomatic therapies as well as dose modification. In addition to surgery and irradiation, sonidegib is an effective and tolerable treatment option for locally advanced basal cell carcinoma that can be expected to work in any age group.