Scholarlink

Introduction <p>Botulinum toxin type A therapies are FDA-approved for the treatment of adult spasticity and recognized as standard of care; however, comparative real-world data on treatment patterns and costs are limited. This study aimed to compare switch rates, healthcare resource utilization (HCRU), and costs among patients with spasticity initiating onabotulinumtoxinA, abobotulinumtoxinA, or incobotulinumtoxinA.</p> Methods <p>Adult patients with spasticity receiving botulinum toxins between January 1, 2017, and December 31, 2023, were&#xa0;identified from Optum’s de-identified Clinformatics<sup>®</sup> Data Mart Database. Patients must have had ≥ 12&#xa0;months of continuous enrollment before and after toxin initiation. Outcomes included switch rates and all-cause, spasticity-related, fall-related, fracture-related, and toxin-related healthcare resource utilization and costs.</p> Results <p>Among 1714 eligible patients, 1521 initiated onabotulinumtoxinA (88.7%), 99 initiated abobotulinumtoxinA (5.8%), and 94 initiated incobotulinumtoxinA (5.5%) as index treatment. Switch rates at 12&#xa0;months post-index were lowest for onabotulinumtoxinA (1.4%) compared with abobotulinumtoxinA (4.0%), and incobotulinumtoxinA (10.6%). OnabotutlinumtoxinA initiators demonstrated lower total all-cause medical costs and fracture-related costs compared with incobotulinumtoxinA and abobotulinumtoxinA, respectively, with comparable healthcare resource utilization and other costs.</p> Conclusion <p>Most patients initiated onabotulinumtoxinA with lower switch rates than those who initiated with incobotulinumtoxinA and abobotulinumtoxinA. Total costs were comparable between treatments, except for all-cause medical costs and fracture-related costs, which were lower among onabotulinumtoxinA initiators.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Real-World Switch Rates, Treatment Patterns, and Healthcare Costs Among Patients With Spasticity Treated With Botulinum Toxins

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月30日

查看全文
  • Annaliza Dominguez,
  • Darshini Shah,
  • Ning Cheng,
  • Shivaji Manthena

摘要

Introduction

Botulinum toxin type A therapies are FDA-approved for the treatment of adult spasticity and recognized as standard of care; however, comparative real-world data on treatment patterns and costs are limited. This study aimed to compare switch rates, healthcare resource utilization (HCRU), and costs among patients with spasticity initiating onabotulinumtoxinA, abobotulinumtoxinA, or incobotulinumtoxinA.

Methods

Adult patients with spasticity receiving botulinum toxins between January 1, 2017, and December 31, 2023, were identified from Optum’s de-identified Clinformatics® Data Mart Database. Patients must have had ≥ 12 months of continuous enrollment before and after toxin initiation. Outcomes included switch rates and all-cause, spasticity-related, fall-related, fracture-related, and toxin-related healthcare resource utilization and costs.

Results

Among 1714 eligible patients, 1521 initiated onabotulinumtoxinA (88.7%), 99 initiated abobotulinumtoxinA (5.8%), and 94 initiated incobotulinumtoxinA (5.5%) as index treatment. Switch rates at 12 months post-index were lowest for onabotulinumtoxinA (1.4%) compared with abobotulinumtoxinA (4.0%), and incobotulinumtoxinA (10.6%). OnabotutlinumtoxinA initiators demonstrated lower total all-cause medical costs and fracture-related costs compared with incobotulinumtoxinA and abobotulinumtoxinA, respectively, with comparable healthcare resource utilization and other costs.

Conclusion

Most patients initiated onabotulinumtoxinA with lower switch rates than those who initiated with incobotulinumtoxinA and abobotulinumtoxinA. Total costs were comparable between treatments, except for all-cause medical costs and fracture-related costs, which were lower among onabotulinumtoxinA initiators.