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<p>Human papillomaviruses (HPV) are very widespread, so that most women and men become infected during their lifetime. In Germany approximately 7850 people are diagnosed with cancer caused by HPV infections every year. In the primary prevention HPV vaccine type-associated precancerous lesions and genital warts can be prevented by early HPV vaccination, such as cervical cancer in about 90% of cases. Interesting further developments such as the reduction to a&#xa0;single HPV vaccination injection or the effect of a&#xa0;postintervention vaccination after conization have not yet been conclusively clarified. After more than 4&#xa0;years of HPV and cytology co-testing in the new screening in women aged&#xa0;35 years and over, the initial analyses by German laboratories indicate positive effects with improved sensitivity and also specificity. A challenge is the increased persistence rate of HPV positive/Pap negative findings in the further course with the necessity to longitudinally evaluate innovative clarification methods, such as dual stain and methylation tests with respect to implementation in the triage routine.</p>

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Zervixkarzinomprävention durch HPV-Impfung und Früherkennung

  • 期刊论文

  • 发表日期：

    2025年5月2日

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  • Peter Hillemanns,
  • Agnieszka Denecke,
  • Jens Hachenberg,
  • Lena Steinkasserer,
  • Matthias Jentschke

摘要

Human papillomaviruses (HPV) are very widespread, so that most women and men become infected during their lifetime. In Germany approximately 7850 people are diagnosed with cancer caused by HPV infections every year. In the primary prevention HPV vaccine type-associated precancerous lesions and genital warts can be prevented by early HPV vaccination, such as cervical cancer in about 90% of cases. Interesting further developments such as the reduction to a single HPV vaccination injection or the effect of a postintervention vaccination after conization have not yet been conclusively clarified. After more than 4 years of HPV and cytology co-testing in the new screening in women aged 35 years and over, the initial analyses by German laboratories indicate positive effects with improved sensitivity and also specificity. A challenge is the increased persistence rate of HPV positive/Pap negative findings in the further course with the necessity to longitudinally evaluate innovative clarification methods, such as dual stain and methylation tests with respect to implementation in the triage routine.