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<p>The cerebellum undergoes significant age-related changes linked to poor balance in older adults. Although multi-session cerebellar iTBS combined with rehabilitation has been used in some clinical populations, its isolated effects in community-dwelling healthy older adults remain unknown, particularly in context of balance control and underlying cerebellar-motor cortex (M1) interactions. We tested whether a single-session, sham-controlled, cerebellar iTBS-only intervention could modulate balance and cerebellar-motor cortex (M1) interactions in community-dwelling older adults without neurological disease. The effects of cerebellar intermittent theta-burst stimulation (iTBS) on balance control and underlying cerebellar-motor cortex (M1) interactions in this population remain unclear. We investigated whether cerebellar iTBS led to [<CitationRef CitationID="CR1">1</CitationRef>] improved standing balance, and [<CitationRef CitationID="CR2">2</CitationRef>] changes in cerebellar-M1interactions measured using cerebellar brain inhibition (CBI) in older adults. Forty older adults were randomized to receive Active (<i>n</i> = 20) or Sham (<i>n</i> = 20) iTBS to the right lateral cerebellum. We measured postural sway (95% ellipse area of the center of pressure) during standing and CBI before iTBS and at multiple time points up to 30&#xa0;min post-stimulation. Compared to sham, a single session of active iTBS reduced postural sway, with balance improvements sustained for at least 30&#xa0;min post-stimulation. Cerebellar iTBS did not significantly alter CBI. Our results support the neuroplastic potential of the cerebellum as a viable target for therapeutic interventions aimed at improving balance in aging, potentially influencing circuits beyond direct cerebellar-M1 motor pathways.</p>

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Enhancing Balance Control in Aging Through Cerebellar Theta-Burst Stimulation

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月8日

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  • Ashwini Sansare,
  • Madison Weinrich,
  • Jessica A. Bernard,
  • Yuming Lei

摘要

The cerebellum undergoes significant age-related changes linked to poor balance in older adults. Although multi-session cerebellar iTBS combined with rehabilitation has been used in some clinical populations, its isolated effects in community-dwelling healthy older adults remain unknown, particularly in context of balance control and underlying cerebellar-motor cortex (M1) interactions. We tested whether a single-session, sham-controlled, cerebellar iTBS-only intervention could modulate balance and cerebellar-motor cortex (M1) interactions in community-dwelling older adults without neurological disease. The effects of cerebellar intermittent theta-burst stimulation (iTBS) on balance control and underlying cerebellar-motor cortex (M1) interactions in this population remain unclear. We investigated whether cerebellar iTBS led to [1] improved standing balance, and [2] changes in cerebellar-M1interactions measured using cerebellar brain inhibition (CBI) in older adults. Forty older adults were randomized to receive Active (n = 20) or Sham (n = 20) iTBS to the right lateral cerebellum. We measured postural sway (95% ellipse area of the center of pressure) during standing and CBI before iTBS and at multiple time points up to 30 min post-stimulation. Compared to sham, a single session of active iTBS reduced postural sway, with balance improvements sustained for at least 30 min post-stimulation. Cerebellar iTBS did not significantly alter CBI. Our results support the neuroplastic potential of the cerebellum as a viable target for therapeutic interventions aimed at improving balance in aging, potentially influencing circuits beyond direct cerebellar-M1 motor pathways.