<p>The Foreword by Dr. Jobes highlights the centrality of the K-12 school setting for playing a key role in youth suicide prevention. Leveraging nearly three decades of research and practice on school-based suicide prevention, this special issue of School Mental Health by editors Drs. Kurt Michael and Amy Brausch is focused on advancing the field by compiling research on universal, secondary, and tertiary supports within the school context to ameliorate the consistently high rates of suicidal thoughts, behaviors, and completions experienced by youths since the turn of the century. Both Drs. Brausch and Michael drew upon their extensive history with school-based partnerships for preventing youth suicide as the impetus for this special issue on contemporary research and the state of the field. Preeminent school-based suicide prevention scholars answered their call to action by broadly covering the suicide prevention continuum, including identification and assistance of at-risk youth, universal prevention strategies, targeted prevention approaches, multi-tiered programming, post-hospitalization school reintegration, and postvention. The research conducted spans various methodological approaches, including systematic reviews, formative and qualitative research, descriptive and correlational research, and experimental studies. Our review and synthesis of the articles herein highlight six emergent themes in school-based suicide prevention: (1) implementing school-wide initiatives, (2) promoting connectedness and belonging for all youth, (3) screening and identifying at-risk youth in need of assistance, (4) strengthening the community stakeholder ecosystem, (5) preparing and responding to suicide in schools, and (6) leveraging implementation science to enhance knowledge translation from research to practice. After briefly summarizing each of these themes, we conclude with a discussion of the key gaps that remain in school-based suicide prevention and directions for future research and practice.</p>