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<p>Post-transplant T-cell lymphomas are an infrequent complication in the setting of prolonged immunosuppression and are typically Epstein-Barr virus (EBV) negative. Herein, we present a case of a 23-year-old individual with history of a kidney transplant who developed multifocal lymphadenopathy and osseous lesions. Biopsy of a spinal lesion demonstrated a T-cell lymphoma with diffuse EBV positivity and CD8 expression. The patient’s disease was refractory to conventional chemotherapy with persistent/recurrent disease in other organ systems showing the aggressive nature of this disease and limited efficacy of standard regimens.</p>

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EBV-positive CD8 + peripheral T-cell lymphoma in the post-transplant setting: case report and review of the literature

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Ahmed A. Ahmed,
  • Shanxiang Zhang,
  • Arash Ronaghy,
  • Safina Hafeez,
  • Dinesh Pradhan,
  • Neha Gupta

摘要

Post-transplant T-cell lymphomas are an infrequent complication in the setting of prolonged immunosuppression and are typically Epstein-Barr virus (EBV) negative. Herein, we present a case of a 23-year-old individual with history of a kidney transplant who developed multifocal lymphadenopathy and osseous lesions. Biopsy of a spinal lesion demonstrated a T-cell lymphoma with diffuse EBV positivity and CD8 expression. The patient’s disease was refractory to conventional chemotherapy with persistent/recurrent disease in other organ systems showing the aggressive nature of this disease and limited efficacy of standard regimens.