<p>Starting from a biosemiotic perspective, my aim in this paper is to review David Bohm’s formulation of “soma-significance”. First of all, I consider that this formulation is innovative regarding the physical-mental relationship since it presents an understanding of meaning as a transitive property across different levels of physical reality. As I will explore in this paper, this understanding deepens the naturalistic perspective in the sense that it moves away from <i>conditio humana</i>, i.e., the idea that meaning is anthropologically centered. Although it is a philosophical virtue of Bohm’s “soma-significance” formulation, I think that (1) we need more than an insight into the relationship between the physical and the mental to make sense of meaning; and (2) the fact that meaning is a transitive property does not imply it is ubiquitous in the universe. These two points drive my reviewing of Bohm’s “soma-significance” formulation as they are converted into an inspiring challenge. From a biosemiotic perspective, I think we need the notion of ‘threshold’ to make sense of meaning as a sign of life instead of taking it to be something that one finds ubiquitously throughout the universe.</p>