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<p>Quercetin (3,5,7,3′,4′-pentahydroxy flavone) is a flavanol that is widely distributed in fruits and vegetables. Apples, onions, scallions, broccoli, and teas all contain it. It has pleiotropic health benefits with some reports suggesting that it can modulate appetite. This research examines the effectiveness of Quercetin supplementation in addressing age-related metabolic issues in a rat model of accelerated senescence. Aged rats showed poor appetite regulation, marked by increased leptin levels and decreased ghrelin levels, along with signs of insulin resistance, lipid abnormalities, and liver dysfunction. Supplementation with Quercetin helped to correct hormonal alterations, improve insulin sensitivity, and restore plasma lipid and liver enzyme profiles to healthier ranges. Four groups of Wistar rats (Rattus norvegicus) were taken, Group I (fed on standard diet), Group II (Quercetin treated with oral dose of 100&#xa0;mg/kg b.w.) Group III (accelerated aging model with D-galactose, 300&#xa0;mg/kg b.w, subcutaneous), Group IV (Quercetin + D-gal) for 28 days. The biochemical parameters were evaluated after rats were sacrificed. Quercetin supplementation regulated hormonal equilibrium, enhanced antioxidant defences, and mitigated inflammation associated with aging, thereby highlighting the potential of Quercetin as an anti-aging agent which may act via appetite regulation and calorie restriction. Our study suggests the impact of natural substances like Quercetin (QCN) in the regulation of metabolic homeostasis and reduction of age-related issues through appetite regulation.</p>

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Quercetin Ameliorates Oxidative Stress, Inflammation and Metabolic Dysregulation in a D-Galactose-Induced Ageing Rat Model Original Research Article

  • 期刊论文

  • 发表日期：

    2026年8月4日

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  • Sakshi Jaiswal,
  • Akanksha Singh,
  • Garima Yadav,
  • Nitin Mishra,
  • Sandeep Yadav,
  • Syed Ibrahim Rizvi

摘要

Quercetin (3,5,7,3′,4′-pentahydroxy flavone) is a flavanol that is widely distributed in fruits and vegetables. Apples, onions, scallions, broccoli, and teas all contain it. It has pleiotropic health benefits with some reports suggesting that it can modulate appetite. This research examines the effectiveness of Quercetin supplementation in addressing age-related metabolic issues in a rat model of accelerated senescence. Aged rats showed poor appetite regulation, marked by increased leptin levels and decreased ghrelin levels, along with signs of insulin resistance, lipid abnormalities, and liver dysfunction. Supplementation with Quercetin helped to correct hormonal alterations, improve insulin sensitivity, and restore plasma lipid and liver enzyme profiles to healthier ranges. Four groups of Wistar rats (Rattus norvegicus) were taken, Group I (fed on standard diet), Group II (Quercetin treated with oral dose of 100 mg/kg b.w.) Group III (accelerated aging model with D-galactose, 300 mg/kg b.w, subcutaneous), Group IV (Quercetin + D-gal) for 28 days. The biochemical parameters were evaluated after rats were sacrificed. Quercetin supplementation regulated hormonal equilibrium, enhanced antioxidant defences, and mitigated inflammation associated with aging, thereby highlighting the potential of Quercetin as an anti-aging agent which may act via appetite regulation and calorie restriction. Our study suggests the impact of natural substances like Quercetin (QCN) in the regulation of metabolic homeostasis and reduction of age-related issues through appetite regulation.