Scholarlink

<p>Lifestyle factors such as cigarette smoking and chronic alcohol consumption are increasingly recognized as major contributors to impaired male reproductive health. The present study evaluated the combined impact of smoking and alcohol intake on semen quality in young adults (N = 112) aged 22–30&#xa0;years attending a fertility clinic. Semen samples were classified into normozoospermia and major infertile phenotypes based on WHO 2021 criteria. Compared with normozoospermic individuals, infertile groups demonstrated a consistent decline in sperm concentration, motility, and normal morphology, accompanied by a marked increase in seminal cadmium accumulation. We observed the elevated Cd concentrations in the infertile groups asthenoteratozoospermia, oligozoospermia, teratozoospermia when compared to the normal group in the current study. In parallel, reduced seminal fructose levels were observed in severe infertile phenotypes, indicating compromised accessory gland function and impaired energy availability for sperm motility. Notably, individuals with combined exposure to cigarette smoking and chronic alcohol consumption exhibited the most pronounced deterioration in semen quality, characterized by severe morphological abnormalities and elevated genomic instability. Collectively, these findings demonstrate a clear association between lifestyle related toxic exposure, oxidative imbalance, and functional as well as molecular sperm damage. The study highlights the synergistic detrimental effects of smoking and alcohol consumption on male fertility and underscores the importance of early lifestyle modification to preserve reproductive health in young men.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

The Effects of Cigarette Smoking and Chronic Alcohol Consumption on Seminal Quality in Young Adults: A Cross-Sectional Study

  • 期刊论文

  • 发表日期：

    2026年3月10日

查看全文
  • Deepanshi Gupta,
  • D. Abilash,
  • A. Dhanesh Gandhi,
  • T. B. Sridharan

摘要

Lifestyle factors such as cigarette smoking and chronic alcohol consumption are increasingly recognized as major contributors to impaired male reproductive health. The present study evaluated the combined impact of smoking and alcohol intake on semen quality in young adults (N = 112) aged 22–30 years attending a fertility clinic. Semen samples were classified into normozoospermia and major infertile phenotypes based on WHO 2021 criteria. Compared with normozoospermic individuals, infertile groups demonstrated a consistent decline in sperm concentration, motility, and normal morphology, accompanied by a marked increase in seminal cadmium accumulation. We observed the elevated Cd concentrations in the infertile groups asthenoteratozoospermia, oligozoospermia, teratozoospermia when compared to the normal group in the current study. In parallel, reduced seminal fructose levels were observed in severe infertile phenotypes, indicating compromised accessory gland function and impaired energy availability for sperm motility. Notably, individuals with combined exposure to cigarette smoking and chronic alcohol consumption exhibited the most pronounced deterioration in semen quality, characterized by severe morphological abnormalities and elevated genomic instability. Collectively, these findings demonstrate a clear association between lifestyle related toxic exposure, oxidative imbalance, and functional as well as molecular sperm damage. The study highlights the synergistic detrimental effects of smoking and alcohol consumption on male fertility and underscores the importance of early lifestyle modification to preserve reproductive health in young men.