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<p>Nearly one billion people are suffering from disabilities of metabolic syndrome. It is essential to identify the occurrence of predictive biomarkers like cytokines in the systemic circulation as they lead to inflammation and immune activation in a healthy population.&#xa0;The study aims at identifying the relationship between the occurrence of metabolic syndrome and inflammation by monitoring circulating cytokines and other metabolic biomarkers in asymptomatic individuals of Trivandrum (South India).The study is a prospective cohort study involving 239 individuals from different strata of the region involving both genders of different socioeconomic backgrounds. Metabolic markers were analysed using an automated clinical chemistry analyser after obtaining anthropometric data and, the cytokines were analysed by ELISA.&#xa0;Participants were comparatively young (mean age 35.71 ± 13.6) majority being females. Physical parameters, metabolic markers, and cytokines exhibited significant age and gender-based differences. 50% of the individuals had a family history of diabetes, while 77% of individuals had dyslipidaemia. Participants with dyslipidaemia had elevated cytokines. When binary logistic regression analysis of individuals without risk factors was compared to individuals with risk factors-diabetes, hypertension, dyslipidaemia, age, Gamma-glutamyl transferase, low urea, high atherogenic lipids, high body mass index, sleep deprivation, cytokines- interleukin-6 and interleukin-17 were dependent to the occurrence of risk factors. A significant correlation was observed between dyslipidaemia and pro-inflammatory cytokines. Control of dyslipidaemia has to be addressed in young individuals, along with thorough follow-up to control risk factors like pro-inflammatory cytokines and immune response to prevent metabolic syndrome and evaluate whether they qualify as predictive markers.</p>

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Systemic Metabolites and Cytokines as Predictive Biomarkers of Metabolic Syndrome in Young Healthy Cohort: A Prospective Study

  • 期刊论文

  • 发表日期：

    2026年2月24日

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  • Reema George,
  • Limi Elizabeth Mathew,
  • Maya G. Pillai,
  • Helen Antony

摘要

Nearly one billion people are suffering from disabilities of metabolic syndrome. It is essential to identify the occurrence of predictive biomarkers like cytokines in the systemic circulation as they lead to inflammation and immune activation in a healthy population. The study aims at identifying the relationship between the occurrence of metabolic syndrome and inflammation by monitoring circulating cytokines and other metabolic biomarkers in asymptomatic individuals of Trivandrum (South India).The study is a prospective cohort study involving 239 individuals from different strata of the region involving both genders of different socioeconomic backgrounds. Metabolic markers were analysed using an automated clinical chemistry analyser after obtaining anthropometric data and, the cytokines were analysed by ELISA. Participants were comparatively young (mean age 35.71 ± 13.6) majority being females. Physical parameters, metabolic markers, and cytokines exhibited significant age and gender-based differences. 50% of the individuals had a family history of diabetes, while 77% of individuals had dyslipidaemia. Participants with dyslipidaemia had elevated cytokines. When binary logistic regression analysis of individuals without risk factors was compared to individuals with risk factors-diabetes, hypertension, dyslipidaemia, age, Gamma-glutamyl transferase, low urea, high atherogenic lipids, high body mass index, sleep deprivation, cytokines- interleukin-6 and interleukin-17 were dependent to the occurrence of risk factors. A significant correlation was observed between dyslipidaemia and pro-inflammatory cytokines. Control of dyslipidaemia has to be addressed in young individuals, along with thorough follow-up to control risk factors like pro-inflammatory cytokines and immune response to prevent metabolic syndrome and evaluate whether they qualify as predictive markers.