<p>A balanced and stable blood vessel homeostasis is a vital concern for the maintenance of a healthy disease free life process. The vessel homeostasis is a complex interplay of many soluble components present in the circulation. The factors like vessel lipid profile and their oxidative state, soluble antioxidant level, molecules to regulate vessel endothelial function, soluble apoptotic molecules and antibodies are the ruling participants for maintaining a balanced systemic blood vessel homeostasis. Any disturbance of the balance may initiate a disease situation. Some of these blood borne factors have been targeted in this study to compare and contrast the differences of blood vessel homeostasis between two life threatening diseases viz. atherosclerosis and carcinogenesis. 50 patients of each category and 25 disease free healthy subjects participated in this study. Subjects were classified into two groups viz. normoglycemic and hyperglycemic. Commercially available kit-protocols for spectrometric estimations and ELISA based commercial kits were used for the assay of the various parameters undertaken in this study. Serum level of total cholesterol, VLDL, LDL and TG were found very high in atherosclerotic subjects and remained to the lower side in carcinogenic patients. The other serum soluble parameters varied in its specific characteristic pattern among the subjects suffering from either atherosclerosis or carcinogenesis. Linear regression analysis of the study components verses serum LDL concentration were explored to decide the deviations of the blood vessel homeostasis between atherosclerosis and carcinogenesis. This study shows a biphasic feature of blood vessel homeostasis in the pathogenesis of atherosclerosis and carcinogenesis.</p>