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<p>Polycystic ovary syndrome is a complex endocrine-metabolic disorder. Various pollutants potentially disrupt the endocrine harmony and leads to this condition. Influence of these exposures on aromatase activity and steroidogenesis is elusive. N = 110 individuals were divided into cases (57) and controls (53). The evaluation was done as per Rotterdam standards. Regular environmental exposures like diet, personal care products, and cook-wares were assessed using a validated questionnaire. LCMS/MS technique was used to test the blood levels of Melamine and Phthalates (DEHP). Aromatase activity was estimated by ELISA and Hormones (Testosterone and Insulin) by ECLIA method. Oxidative stress was measured by estimating Malondialdehyde (MDA) concentrations using spectrophotometry. Statistical analysis was conducted utilizing SPSS<i>version</i>19 software. DEHP (19.68 ± 8.23&#xa0;ng/mL) and MDA (1.53 ± 1.01&#xa0;µM/L) were markedly elevated in PCOS patients compared with controls. Elevated MDA demonstrated a significant association with increased testosterone (r = 0.231, <i>p</i> &lt; 0. 05) and reduced aromatase activity (r = − 0.204, <i>p</i> &lt; 0. 05). DEHP showed a strong negative correlation with serum testosterone (r = –0.315, <i>p</i> &lt; 0. 05). In addition, body lotion emerged as the main exposure in PCOS women and was strongly linked to PCOS (OR≈2.9, <i>p</i> &lt; 0.05), while regular non-stick cookware use showed a significant negative correlation with aromatase (<i>r</i> = − 0.224, <i>p</i>0.019) and a positive correlation with testosterone (<i>r</i> = 0.240, <i>p</i>0.012). Melamine remained undetected in all serum samples. In conclusion, Higher oxidative stress appear to suppress aromatase activity, contributing to testosterone accumulation, while increased DEHP levels and their inverse correlation with testosterone reflects the influence of plastic-derived toxicants on steroidogenesis.</p>

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Evaluation of Steroidogenesis Inhibition by Environmental Exposures in Polycystic Ovary Syndrome (PCOS): A Case–Control Study

  • 期刊论文

  • 发表日期：

    2026年1月20日

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  • S. Narayana,
  • N. Suchetha Kumari,
  • Chandrika Anand,
  • Prasanna Kumar Shetty,
  • H. P. Shruthi,
  • S. V. Suresh Babu

摘要

Polycystic ovary syndrome is a complex endocrine-metabolic disorder. Various pollutants potentially disrupt the endocrine harmony and leads to this condition. Influence of these exposures on aromatase activity and steroidogenesis is elusive. N = 110 individuals were divided into cases (57) and controls (53). The evaluation was done as per Rotterdam standards. Regular environmental exposures like diet, personal care products, and cook-wares were assessed using a validated questionnaire. LCMS/MS technique was used to test the blood levels of Melamine and Phthalates (DEHP). Aromatase activity was estimated by ELISA and Hormones (Testosterone and Insulin) by ECLIA method. Oxidative stress was measured by estimating Malondialdehyde (MDA) concentrations using spectrophotometry. Statistical analysis was conducted utilizing SPSSversion19 software. DEHP (19.68 ± 8.23 ng/mL) and MDA (1.53 ± 1.01 µM/L) were markedly elevated in PCOS patients compared with controls. Elevated MDA demonstrated a significant association with increased testosterone (r = 0.231, p < 0. 05) and reduced aromatase activity (r = − 0.204, p < 0. 05). DEHP showed a strong negative correlation with serum testosterone (r = –0.315, p < 0. 05). In addition, body lotion emerged as the main exposure in PCOS women and was strongly linked to PCOS (OR≈2.9, p < 0.05), while regular non-stick cookware use showed a significant negative correlation with aromatase (r = − 0.224, p0.019) and a positive correlation with testosterone (r = 0.240, p0.012). Melamine remained undetected in all serum samples. In conclusion, Higher oxidative stress appear to suppress aromatase activity, contributing to testosterone accumulation, while increased DEHP levels and their inverse correlation with testosterone reflects the influence of plastic-derived toxicants on steroidogenesis.