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<p>The research highlights the protective effects of DL-α-Lipoic acid (LA) at a dosage of 25&#xa0;mg/kg body weight, along with meso 2, 3-dimercaptosuccinic acid (DMSA) at 20&#xa0;mg/kg body weight intraperitoneally (i.p), against nephrotoxicity caused by lead exposure, focusing on their influence on glucose metabolism and energy production in the kidneys of male albino Wistar rats. Renal impairment was observed in rats exposed to 0.2% lead acetate (Pb), marked by reduced enzyme activity essential for kidney function, such as alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and β-glucuronidase (GUSB). Additionally, a shift in renal metabolism was identified, which was characterized by reduced activity of glycolytic enzymes and enhanced activity of gluconeogenic enzymes. Furthermore, the activity of Krebs cycle enzymes was significantly reduced, along with a marked decrease in membrane-bound phosphohydrolases. The administration of LA and DMSA, either alone or together, effectively reversed the disturbances in enzyme activities associated with renal metabolism. Improvement of the overall renal architecture by histopathology and transmission electron microscopy studies confirms restoration of cell structure and function. The combined use of an antioxidant LA and a chelating agent DMSA presents a promising therapeutic approach to mitigate the biochemical imbalances caused by lead toxicity.</p>

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Combined Effects of Lipoic Acid and Dimercaptosuccinic Acid in Improving Lead-Induced Alterations on Glucose Metabolism, Energy Metabolism and Tissue Histology

  • 期刊论文

  • 发表日期：

    2025年7月1日

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  • Sivaprasad Rajagopalan,
  • Malarkodi Kumaravel Palanichamy

摘要

The research highlights the protective effects of DL-α-Lipoic acid (LA) at a dosage of 25 mg/kg body weight, along with meso 2, 3-dimercaptosuccinic acid (DMSA) at 20 mg/kg body weight intraperitoneally (i.p), against nephrotoxicity caused by lead exposure, focusing on their influence on glucose metabolism and energy production in the kidneys of male albino Wistar rats. Renal impairment was observed in rats exposed to 0.2% lead acetate (Pb), marked by reduced enzyme activity essential for kidney function, such as alkaline phosphatase (ALP), lactate dehydrogenase (LDH), and β-glucuronidase (GUSB). Additionally, a shift in renal metabolism was identified, which was characterized by reduced activity of glycolytic enzymes and enhanced activity of gluconeogenic enzymes. Furthermore, the activity of Krebs cycle enzymes was significantly reduced, along with a marked decrease in membrane-bound phosphohydrolases. The administration of LA and DMSA, either alone or together, effectively reversed the disturbances in enzyme activities associated with renal metabolism. Improvement of the overall renal architecture by histopathology and transmission electron microscopy studies confirms restoration of cell structure and function. The combined use of an antioxidant LA and a chelating agent DMSA presents a promising therapeutic approach to mitigate the biochemical imbalances caused by lead toxicity.