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<p>The erythrocyte sedimentation rate (ESR) is widely used in clinical practice. While the Westergren method remains the traditional reference, automated systems like the Mini Cube offer faster processing and enhanced biosafety. This study aimed to assess the correlation between the Mini Cube and Westergren methods and to evaluate their relationship with haemoglobin (Hb) and packed cell volume (PCV). A retrospective analysis of 155 paired samples was performed. ESR was measured simultaneously using the Mini Cube analyser and the Westergren method. Hb and PCV values were obtained from complete blood counts. Statistical analysis included descriptive statistics, Pearson’s correlation, and linear regression. A very strong positive correlation was observed between the Mini Cube and Westergren methods (<i>r</i> = 0.932, <i>p</i> &lt; 0.0001). The Westergren method showed a consistent positive bias with a mean difference of + 5.58&#xa0;mm/hr. Regression analysis yielded the formula: <i>Westergren ESR = 5.24 + (1.03 × Mini Cube ESR)</i> (R² = 0.869). Both methods demonstrated strong inverse correlations with PCV (<i>r</i> ≈ -0.56) and Hb (<i>r</i> ≈ -0.53). The Mini Cube demonstrates excellent agreement with the Westergren method and accurately reflects expected haematological relationships. Despite a systematic bias, it represents a reliable and efficient alternative for ESR measurement. Use of method-specific reference intervals is recommended for accurate interpretation.</p>

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Comparative Evaluation of the Mini Cube Automated ESR Analyzer and the Standard Westergren Method: Correlation with Haemoglobin and Packed Cell Volume

  • 期刊论文

  • 发表日期：

    2026年5月30日

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  • Pawan Dhull,
  • Shipra Verma,
  • Robin Choudhary,
  • Sanjeevan Sharma,
  • Ritika Bhatia

摘要

The erythrocyte sedimentation rate (ESR) is widely used in clinical practice. While the Westergren method remains the traditional reference, automated systems like the Mini Cube offer faster processing and enhanced biosafety. This study aimed to assess the correlation between the Mini Cube and Westergren methods and to evaluate their relationship with haemoglobin (Hb) and packed cell volume (PCV). A retrospective analysis of 155 paired samples was performed. ESR was measured simultaneously using the Mini Cube analyser and the Westergren method. Hb and PCV values were obtained from complete blood counts. Statistical analysis included descriptive statistics, Pearson’s correlation, and linear regression. A very strong positive correlation was observed between the Mini Cube and Westergren methods (r = 0.932, p < 0.0001). The Westergren method showed a consistent positive bias with a mean difference of + 5.58 mm/hr. Regression analysis yielded the formula: Westergren ESR = 5.24 + (1.03 × Mini Cube ESR) (R² = 0.869). Both methods demonstrated strong inverse correlations with PCV (r ≈ -0.56) and Hb (r ≈ -0.53). The Mini Cube demonstrates excellent agreement with the Westergren method and accurately reflects expected haematological relationships. Despite a systematic bias, it represents a reliable and efficient alternative for ESR measurement. Use of method-specific reference intervals is recommended for accurate interpretation.