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<p>Among children undergoing treatment for hematology–oncology disorders in low-resource settings, infections remain a leading cause of treatment-related death. The incidence of culture proven sepsis in these patients is very low. Soluble CD14 (sCD14) or presepsin, a recently identified biomarker, shows potential for the early recognition of sepsis in these children. To assess the levels of sCD14 in febrile neutropenic patients and compare it with controls; and to correlate the levels of sCD14 with absolute neutrophil counts (ANC), C-reactive protein(CRP) and procalcitonin (PCT) in febrile neutropenic (FN) patients. Cross-sectional study carried out in a tertiary care teaching institute in Northern India. 38 febrile neutropenic cases were compared with 38 afebrile pediatric haematology and oncology patients. CRP was elevated in all cases and in 31.58% controls. Procalcitonin levels were elevated in 81.58% cases and 28.95% controls. sCD14 levels were elevated in 36.84% cases but were normal in all controls. The mean values of CRP, procalcitonin and sCD14 were significantly higher in cases than controls. Blood or urine culture was positive in only 15.79% cases. The levels of sCD14 were significantly higher in culture positive cases. No significant difference was seen in CRP and procalcitonin levels. sCD14 appears to be a promising biomarker for the detection of sepsis/ UTI in pediatric FN cases than CRP or PCT.</p>

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Soluble CD 14 – An Emerging Marker in Febrile Neutropenia in Children

  • 期刊论文

  • 发表日期：

    2026年4月4日

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  • Dawa Norbu Kharmo,
  • Alok Hemal,
  • Anubhuti,
  • Shilpa Khanna Arora

摘要

Among children undergoing treatment for hematology–oncology disorders in low-resource settings, infections remain a leading cause of treatment-related death. The incidence of culture proven sepsis in these patients is very low. Soluble CD14 (sCD14) or presepsin, a recently identified biomarker, shows potential for the early recognition of sepsis in these children. To assess the levels of sCD14 in febrile neutropenic patients and compare it with controls; and to correlate the levels of sCD14 with absolute neutrophil counts (ANC), C-reactive protein(CRP) and procalcitonin (PCT) in febrile neutropenic (FN) patients. Cross-sectional study carried out in a tertiary care teaching institute in Northern India. 38 febrile neutropenic cases were compared with 38 afebrile pediatric haematology and oncology patients. CRP was elevated in all cases and in 31.58% controls. Procalcitonin levels were elevated in 81.58% cases and 28.95% controls. sCD14 levels were elevated in 36.84% cases but were normal in all controls. The mean values of CRP, procalcitonin and sCD14 were significantly higher in cases than controls. Blood or urine culture was positive in only 15.79% cases. The levels of sCD14 were significantly higher in culture positive cases. No significant difference was seen in CRP and procalcitonin levels. sCD14 appears to be a promising biomarker for the detection of sepsis/ UTI in pediatric FN cases than CRP or PCT.