Scholarlink

<p>ABO isoagglutinin can cause severe intravascular hemolysis, renal failure and death in transfused patients. They also play a significant role in the outcome of ABO incompatible grafts in both solid organs as well as hematopoietic stem cell transplants. The present study was aimed at identifying prevalence of high titer (IgG/IgM) group O blood donors. 300 blood group O donors were selected by simple randomization. Blood donors’ antibody titration for IgM was done by serial dilution of plasma at 24<sup>0</sup> C by conventional tube technique. After that, DTT treatment of plasma was carried out and antibody titration for IgG antibodies was done. The median antibody titers in females were greater than those in men in general. A higher median antibody titer was seen in the higher age group for anti-B IgM (64) and anti-A IgG (64). There was a positive correlation between different antibody titer. The mean ABO antibody titers (IgG and IgM) in O group donors in our region are notably high. Therefore, antibody titration might be considered for all O group single donor platelets and prior to group O whole blood transfusion in trauma.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prevalence of High ABO - Antibody Titers in O blood Group Donors: An Observation from Eastern India

  • 期刊论文

  • 发表日期：

    2026年4月1日

查看全文
  • Soumyarupa Majee,
  • Atanu Biswas,
  • Suman Halder,
  • Prasun Bhattacharya,
  • Krishnendu Mukherjee

摘要

ABO isoagglutinin can cause severe intravascular hemolysis, renal failure and death in transfused patients. They also play a significant role in the outcome of ABO incompatible grafts in both solid organs as well as hematopoietic stem cell transplants. The present study was aimed at identifying prevalence of high titer (IgG/IgM) group O blood donors. 300 blood group O donors were selected by simple randomization. Blood donors’ antibody titration for IgM was done by serial dilution of plasma at 240 C by conventional tube technique. After that, DTT treatment of plasma was carried out and antibody titration for IgG antibodies was done. The median antibody titers in females were greater than those in men in general. A higher median antibody titer was seen in the higher age group for anti-B IgM (64) and anti-A IgG (64). There was a positive correlation between different antibody titer. The mean ABO antibody titers (IgG and IgM) in O group donors in our region are notably high. Therefore, antibody titration might be considered for all O group single donor platelets and prior to group O whole blood transfusion in trauma.