<p>To determine the prevalence of neonatal thrombocytopenia and immature platelet fraction (IPF) among neonates born to mothers with hypertensive disorders of pregnancy (HDP) including preeclampsia and eclampsia. This was a hospital based observational study included 133 newborns born to mothers with mothers with HDP and apparently healthy 100 newborns born to normotensive mothers as control. Hemogram including IPF, was assessed in all neonates within the first 24&#xa0;h of life. Thrombocytopenia was found in 39(29.32%) newborns of mothers with HDP, as compare to 4%(<i>n</i> = 4) in the control group. Of the total 39 thrombocytopenic babies 6(15.38%) had severe, 11(28.21%) had moderate, and 22(56.41%) had mild thrombocytopenia. Platelets count was significantly low in newborns of mothers with HDP, as compared to controls (193.69 ± 75.98 × 10³/µL; 235.08 ± 63.08 × 10³/µL, <i>p</i> &lt; 0.005). Additionally, newborn of mothers with HDP had significantly higher value of IPF (1.51 ± 0.08% vs. 1.30 ± 0.64%, <i>p</i> &lt; 0.05). Thrombocytopenic babies (<i>n</i> = 39) had significantly low mean platelet count and higher mean IPF value as compare to non-thrombocytopenic babies (<i>n</i> = 94) born to mothers with HDP (p-value &lt; 0.001). Males, small for gestational age (SGA), preterm, and low birth weight (LBW) newborns were associated with significantly higher percentage of overall thrombocytopenia. A significantly higher percentage of overall and severe thrombocytopenia was observed in newborns of maternal gestational age at HDP onset of ≤ 30 weeks. This study marks a significant milestone by utilizing IPF for the first time to understand the underlying mechanism of neonatal thrombocytopenia that is more prevalent in newborn of mothers with HDP. This is not due to bone marrow suppression as supported by higher IPF values; instead, could be due to peripheral destructive causes.</p>