Scholarlink

<p>Patients with rheumatoid arthritis (RA) incur twice the risk for adverse cardiovascular outcomes compared to the general population, possibly mediated by platelet dysfunction. This study aimed to determine if platelet hyperaggregability is associated with RA. We recruited 17 adults diagnosed with RA (according to ACR/EULAR 2010 criteria) and 17 age- and sex-matched disease-free controls from a tertiary rheumatology clinic in South India. Collected data included demographics, comorbidities, baseline cardiovascular risk, and, for the RA group, indices of disease activity. Platelet aggregation was analyzed using light transmission aggregometry with low-dose adenosine diphosphate (ADP, 0.4&#xa0;µmol/L) as agonist. Max-A% indicated maximum irreversible light transmission at five minutes post-agonist, with hyperaggregability defined as Max-A% over 50%. Mean participant age was 46&#xa0;years, with a female majority (73.5%). The two groups were similar in demographics and cardiovascular risk. However, platelet hyperaggregability was found in 41.2% of RA patients compared to 11.7% of controls (odds ratio: 4.1, 95% CI: 0.8–21.7). Platelet hyperaggregability showed a strong positive correlation with tender and swollen joint counts, but a weaker correlation with overall disease activity scores. Platelet hyperaggregability appears associated with RA disease activity, warranting further research into its role in immunothrombosis and increasing cardiovascular risk.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Inflammation-Driven Platelet Hyperaggregability in Rheumatoid Arthritis – A Cross-Sectional Study

  • 期刊论文

  • 发表日期：

    2026年3月14日

查看全文
  • Spoorthy Raj D.R,
  • Mithun C.B,
  • Suma Balan,
  • Jyothi Visalakshy Srikanth,
  • Manu Pradeep,
  • Sandeep Surendran

摘要

Patients with rheumatoid arthritis (RA) incur twice the risk for adverse cardiovascular outcomes compared to the general population, possibly mediated by platelet dysfunction. This study aimed to determine if platelet hyperaggregability is associated with RA. We recruited 17 adults diagnosed with RA (according to ACR/EULAR 2010 criteria) and 17 age- and sex-matched disease-free controls from a tertiary rheumatology clinic in South India. Collected data included demographics, comorbidities, baseline cardiovascular risk, and, for the RA group, indices of disease activity. Platelet aggregation was analyzed using light transmission aggregometry with low-dose adenosine diphosphate (ADP, 0.4 µmol/L) as agonist. Max-A% indicated maximum irreversible light transmission at five minutes post-agonist, with hyperaggregability defined as Max-A% over 50%. Mean participant age was 46 years, with a female majority (73.5%). The two groups were similar in demographics and cardiovascular risk. However, platelet hyperaggregability was found in 41.2% of RA patients compared to 11.7% of controls (odds ratio: 4.1, 95% CI: 0.8–21.7). Platelet hyperaggregability showed a strong positive correlation with tender and swollen joint counts, but a weaker correlation with overall disease activity scores. Platelet hyperaggregability appears associated with RA disease activity, warranting further research into its role in immunothrombosis and increasing cardiovascular risk.