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<p>A 71-year-old man presented with cytopenias and splenomegaly. Diagnostic workup revealed T-cell large granular lymphocytic leukemia (T-LGLL), characterized by a clonal CD8+ T-cell population with <i>STAT3</i> mutation. A rare morphological finding of myeloperoxidase-negative Auer rod-like inclusions in the leukemic lymphocytes was observed, a feature seldom reported in this T-cell malignancy.</p>

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Auer Rod–Like Inclusions in T-cell Large Granular Lymphocytic Leukaemia

  • 期刊论文

  • 发表日期：

    2025年11月21日

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  • Hongwei Chen,
  • Meixuan Chen

摘要

A 71-year-old man presented with cytopenias and splenomegaly. Diagnostic workup revealed T-cell large granular lymphocytic leukemia (T-LGLL), characterized by a clonal CD8+ T-cell population with STAT3 mutation. A rare morphological finding of myeloperoxidase-negative Auer rod-like inclusions in the leukemic lymphocytes was observed, a feature seldom reported in this T-cell malignancy.