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<p>Sickle cell disease (SCD) is an inherited condition caused by abnormal hemoglobin, leading to severe complications like strokes and silent cerebral infarcts. Early screening with transcranial Doppler and regular blood transfusions significantly reduce stroke risk. Updated guidelines emphasize these preventive measures for better outcomes. The study aims to evaluate the prevalence of neurological complications, such as CVA, among Sudanese SCD patients and estimate their impact. This study reviewed records of SCD patients aged 2–15 at Albuluk Children’s Hospital (2017–2019), excluding those with other CNS conditions. The study of 117 SCD patients found that 11.1% developed CVA, with (76.9%) of cases linked to low-moderate socioeconomic status, positive family history, severe anemia, and high WBC levels. Limited access to TCD, MRI, and blood transfusion posed significant challenges. Key predictors of stroke in SCD patients include age 2–5&#xa0;years, chest syndrome, low hemoglobin levels, and high WBC counts. Stroke prevalence is higher in regions lacking advanced preventive measures like TCD, MRI, and regular blood transfusions.</p>

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Predictors of Cerebrovascular Accident Among Sudanese Children with Sickle Cell Anemia

  • 期刊论文

  • 发表日期：

    2025年7月5日

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  • Karimeldin Mohamed Ali Salih

摘要

Sickle cell disease (SCD) is an inherited condition caused by abnormal hemoglobin, leading to severe complications like strokes and silent cerebral infarcts. Early screening with transcranial Doppler and regular blood transfusions significantly reduce stroke risk. Updated guidelines emphasize these preventive measures for better outcomes. The study aims to evaluate the prevalence of neurological complications, such as CVA, among Sudanese SCD patients and estimate their impact. This study reviewed records of SCD patients aged 2–15 at Albuluk Children’s Hospital (2017–2019), excluding those with other CNS conditions. The study of 117 SCD patients found that 11.1% developed CVA, with (76.9%) of cases linked to low-moderate socioeconomic status, positive family history, severe anemia, and high WBC levels. Limited access to TCD, MRI, and blood transfusion posed significant challenges. Key predictors of stroke in SCD patients include age 2–5 years, chest syndrome, low hemoglobin levels, and high WBC counts. Stroke prevalence is higher in regions lacking advanced preventive measures like TCD, MRI, and regular blood transfusions.