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<p>Odontogenic diseases of the maxillary sinuses encompass a&#xa0;broad spectrum of inflammatory, cystic and neoplastic lesions, the clinical and radiological differentiation of which is often challenging. As a&#xa0;prototypical example of a&#xa0;maxillary sinus disease of odontogenic origin, chronic odontogenic rhinosinusitis exhibits certain histopathological differences to classical chronic rhinosinusitis. Furthermore, depending on the specific odontogenic cause, certain histopathological patterns may be observed. Odontogenic cysts represent a&#xa0;diagnostic challenge, as their histological appearance is often altered by inflammatory changes. This may also impair the diagnostic certainty of odontogenic keratocysts in biopsy material. Reliable histopathological distinction between individual entities therefore requires incorporation of clinical and radiological information. Detection of the common <i>BRAF </i>V600E mutation in ameloblastomas can increase the diagnostic certainty. The present overview underscores the importance of standardized histological assessment and functioning communication between clinicians, radiologists, and pathologists in order to accurately classify odontogenic diseases of the maxillary sinuses.</p>

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Pathologie odontogener Kieferhöhlenerkrankungen

  • 期刊论文

  • 发表日期：

    2026年4月13日

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  • Leander Schwaibold,
  • Falko Fend,
  • Siegmar Reinert,
  • Michael Krimmel,
  • Robert Rottscholl

摘要

Odontogenic diseases of the maxillary sinuses encompass a broad spectrum of inflammatory, cystic and neoplastic lesions, the clinical and radiological differentiation of which is often challenging. As a prototypical example of a maxillary sinus disease of odontogenic origin, chronic odontogenic rhinosinusitis exhibits certain histopathological differences to classical chronic rhinosinusitis. Furthermore, depending on the specific odontogenic cause, certain histopathological patterns may be observed. Odontogenic cysts represent a diagnostic challenge, as their histological appearance is often altered by inflammatory changes. This may also impair the diagnostic certainty of odontogenic keratocysts in biopsy material. Reliable histopathological distinction between individual entities therefore requires incorporation of clinical and radiological information. Detection of the common BRAF V600E mutation in ameloblastomas can increase the diagnostic certainty. The present overview underscores the importance of standardized histological assessment and functioning communication between clinicians, radiologists, and pathologists in order to accurately classify odontogenic diseases of the maxillary sinuses.