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Background <p>&#xa0;Therapeutic mammoplasty (TM) is a well-established oncoplastic breast-conserving technique, particularly for patients with large ptotic breasts. However, evidence on the oncologic safety and cosmetic outcomes in East Asian patients who meet these anatomical criteria remains limited. This study evaluated the outcomes of TM combined with contralateral reduction mammoplasty in a cohort of East Asians.</p> Methods <p>&#xa0;We conducted a single-center retrospective observational study of consecutive patients who underwent TM with simultaneous contralateral reduction mammoplasty for breast cancer between April 2014 and March 2024. The primary endpoint was oncologic safety, assessed using the positive margin rate and local recurrence. The secondary endpoints included 1-year cosmetic outcomes, assessed using BCCT.core and the Harvard scale by blinded physicians.</p> Results <p>A total of 104 patients were included (mean age: 59.6 ± 10.6&#xa0;years, mean body mass index: 28.4 ± 5.1&#xa0;kg/m<sup>2</sup>, mean tumor size: 22.0 ± 11.5&#xa0;mm). Positive margins occurred in 5 patients; 4 underwent additional resection and 1 received boost irradiation alone. At a median follow-up of 58.6&#xa0;months, no local recurrence occurred, whereas distant recurrence occurred in 1 patient. Perioperative complications occurred in 27 patients, with 6 requiring reoperation; no cases of nipple necrosis were reported. Among 100 evaluable patients, excellent or good cosmetic outcomes were achieved in 83.0% and 79.0% according to BCCT.core and the Harvard scale, respectively. Boost irradiation and perioperative chemotherapy were associated with poor cosmetic outcomes.</p> Conclusions <p>&#xa0;In selected East Asian patients with relatively large ptotic breasts, TM combined with contralateral reduction mammoplasty demonstrated favorable oncologic safety and cosmetic outcomes.</p>

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Therapeutic mammoplasty in selected East Asian patients: oncologic safety and cosmetic outcomes

  • 期刊论文

  • 发表日期：

    2026年7月31日

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  • Ryohei Katsuragi,
  • Hisamitsu Zaha,
  • Norie Abe,
  • Shunichiro Orihara,
  • Maho Okiyama,
  • Ayako Koki,
  • Toshihiko Satake

摘要

Background

 Therapeutic mammoplasty (TM) is a well-established oncoplastic breast-conserving technique, particularly for patients with large ptotic breasts. However, evidence on the oncologic safety and cosmetic outcomes in East Asian patients who meet these anatomical criteria remains limited. This study evaluated the outcomes of TM combined with contralateral reduction mammoplasty in a cohort of East Asians.

Methods

 We conducted a single-center retrospective observational study of consecutive patients who underwent TM with simultaneous contralateral reduction mammoplasty for breast cancer between April 2014 and March 2024. The primary endpoint was oncologic safety, assessed using the positive margin rate and local recurrence. The secondary endpoints included 1-year cosmetic outcomes, assessed using BCCT.core and the Harvard scale by blinded physicians.

Results

A total of 104 patients were included (mean age: 59.6 ± 10.6 years, mean body mass index: 28.4 ± 5.1 kg/m2, mean tumor size: 22.0 ± 11.5 mm). Positive margins occurred in 5 patients; 4 underwent additional resection and 1 received boost irradiation alone. At a median follow-up of 58.6 months, no local recurrence occurred, whereas distant recurrence occurred in 1 patient. Perioperative complications occurred in 27 patients, with 6 requiring reoperation; no cases of nipple necrosis were reported. Among 100 evaluable patients, excellent or good cosmetic outcomes were achieved in 83.0% and 79.0% according to BCCT.core and the Harvard scale, respectively. Boost irradiation and perioperative chemotherapy were associated with poor cosmetic outcomes.

Conclusions

 In selected East Asian patients with relatively large ptotic breasts, TM combined with contralateral reduction mammoplasty demonstrated favorable oncologic safety and cosmetic outcomes.