Purpose of Review <p>To review the current literature to understand and analyze the impact of climate change on the spatial dynamics of primary cutaneous coccidioidomycosis.</p> Recent Findings <p>Establishing a causal relationship between climate change and the incidence of primary cutaneous coccidioidomycosis is challenging due to the low number of reported cases. Strong evidence that climate change has altered the epidemiology of pulmonary coccidioidomycosis suggests the same impact on cutaneous infection.</p> Summary <p>Global warming, climate migration, and extreme weather events have led to changes in the spatial dynamics of coccidioidomycosis, both in its pulmonary and primary cutaneous forms, despite being a rare clinical entity. Currently, primary cutaneous coccidioidomycosis should be considered in the differential diagnosis of unusual skin lesions that occur in people living in areas traditionally known to be endemic, as well as in those that are not.</p>