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Purpose of Review <p>To explore the therapeutic potential and formulation strategies of microsponge-based drug delivery systems for enhancing the efficacy of phytochemical-derived antifungal agents against dermatophytic infections.</p> Recent Findings <p>Recent preclinical studies have shown that encapsulating phytochemicals such as eugenol, thymol, berberine, and tea tree oil in microsponges enhances drug stability, promotes controlled release, improves skin penetration, and reduces systemic toxicity compared to conventional formulations. Microsponge formulations demonstrated sustained antifungal activity, reduced recurrence rates, and better safety profiles in vitro and in vivo models.</p> Summary <p>Microsponge technology offers a promising delivery platform for phytochemicals with antifungal properties by overcoming challenges like low solubility, instability, and poor skin retention. This integration bridges traditional herbal remedies with advanced drug delivery systems, potentially improving clinical outcomes in the treatment of dermatophytic infections.</p>

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Innovative Microsponges-Based Delivery Systems for Phytochemical-Derived Anti-Dermatophyte Agents: Bridging Traditional Medicine and Advanced Drug Delivery

  • 期刊论文

  • 发表日期：

    2025年8月26日

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  • Pavithra K. B,
  • Chamundeeswari D,
  • Jayasurya Ramesh,
  • Mounika Gunasekaran,
  • Pugazhendhi Sarangapani

摘要

Purpose of Review

To explore the therapeutic potential and formulation strategies of microsponge-based drug delivery systems for enhancing the efficacy of phytochemical-derived antifungal agents against dermatophytic infections.

Recent Findings

Recent preclinical studies have shown that encapsulating phytochemicals such as eugenol, thymol, berberine, and tea tree oil in microsponges enhances drug stability, promotes controlled release, improves skin penetration, and reduces systemic toxicity compared to conventional formulations. Microsponge formulations demonstrated sustained antifungal activity, reduced recurrence rates, and better safety profiles in vitro and in vivo models.

Summary

Microsponge technology offers a promising delivery platform for phytochemicals with antifungal properties by overcoming challenges like low solubility, instability, and poor skin retention. This integration bridges traditional herbal remedies with advanced drug delivery systems, potentially improving clinical outcomes in the treatment of dermatophytic infections.