Scholarlink

Purpose of Review <p>Fungal infections pose a significant health challenge due to their diverse manifestations and the growing problem of antifungal resistance. Current treatment options, including conventional formulations and even some nano-delivery systems, often suffer from limitations in drug delivery, particularly across skin barriers. This review explores the potential of transferosomes as a promising alternative for enhanced antifungal drug delivery.</p> Recent Findings <p>Conventional antifungal formulations face challenges in penetration and bioavailability, particularly due to the lipophilic nature of antifungal moieties and their difficulty in crossing the stratum corneum. Nano-delivery systems, such as transferosomes, niosomes, and liposomes, have been investigated for improved drug transport. Transferosomes, ultra-deformable vesicular carrier systems, have emerged as a potential solution for overcoming the challenges associated with transdermal drug delivery. Their unique properties, including small size, low polydispersity index (PDI), high encapsulation efficiency, sustained release capabilities, and biocompatibility, make them attractive candidates for delivering antifungal agents. Studies have shown that transferosomes can effectively penetrate skin membranes and reach deeper tissues, potentially improving the treatment of fungal infections. This review examines the mechanisms by which transferosomes facilitate drug transport and highlights their advantages over other delivery methods.</p> Summary <p>This review provides a comprehensive overview of the current challenges in treating fungal infections, focusing on the limitations of conventional and some nano-based drug delivery systems. It then explores the potential of transferosomes as a superior alternative for enhancing the delivery of antifungal drugs, particularly for cutaneous and subcutaneous infections. The review discusses the key characteristics of transferosomes that contribute to their effectiveness and underscores their potential to improve treatment outcomes for fungal diseases by overcoming barrier-related issues and enhancing drug penetration and permeability.</p> Graphical Abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Transferosomes As A Promising Platform for Targeted Antifungal Drug Delivery

  • 期刊论文

  • 发表日期：

    2025年9月5日

查看全文
  • Yashmi Jain,
  • Geetika Jain,
  • Dakshita Dutta,
  • Manish Yadav

摘要

Purpose of Review

Fungal infections pose a significant health challenge due to their diverse manifestations and the growing problem of antifungal resistance. Current treatment options, including conventional formulations and even some nano-delivery systems, often suffer from limitations in drug delivery, particularly across skin barriers. This review explores the potential of transferosomes as a promising alternative for enhanced antifungal drug delivery.

Recent Findings

Conventional antifungal formulations face challenges in penetration and bioavailability, particularly due to the lipophilic nature of antifungal moieties and their difficulty in crossing the stratum corneum. Nano-delivery systems, such as transferosomes, niosomes, and liposomes, have been investigated for improved drug transport. Transferosomes, ultra-deformable vesicular carrier systems, have emerged as a potential solution for overcoming the challenges associated with transdermal drug delivery. Their unique properties, including small size, low polydispersity index (PDI), high encapsulation efficiency, sustained release capabilities, and biocompatibility, make them attractive candidates for delivering antifungal agents. Studies have shown that transferosomes can effectively penetrate skin membranes and reach deeper tissues, potentially improving the treatment of fungal infections. This review examines the mechanisms by which transferosomes facilitate drug transport and highlights their advantages over other delivery methods.

Summary

This review provides a comprehensive overview of the current challenges in treating fungal infections, focusing on the limitations of conventional and some nano-based drug delivery systems. It then explores the potential of transferosomes as a superior alternative for enhancing the delivery of antifungal drugs, particularly for cutaneous and subcutaneous infections. The review discusses the key characteristics of transferosomes that contribute to their effectiveness and underscores their potential to improve treatment outcomes for fungal diseases by overcoming barrier-related issues and enhancing drug penetration and permeability.

Graphical Abstract