Purpose of Review <p>This review provides an in-depth analysis of histoplasmosis, with a special focus on its cutaneous manifestations. It covers etiological factors, pathogenic mechanisms (especially in immunocompromised individuals), diagnostic methods, clinical presentations, and treatment strategies. Additionally, it explores public health implications and future research directions.</p> Recent Findings <p>Recent studies highlight the global spread of histoplasmosis, especially in immunocompromised individuals, such as individuals with HIV/AIDS. Advances in diagnostics, such as LFAs and PCR, have improved accuracy, but cutaneous histoplasmosis remains underrecognized. Current treatment strategies emphasize antifungal agents like itraconazole and amphotericin B, with liposomal amphotericin B showing promise for severe cases, particularly in immunocompromised individuals.</p> Summary <p>Histoplasmosis ranges from asymptomatic to severe disseminated forms, often affecting the skin in immunocompromised patients. Diagnosis is challenging due to nonspecific symptoms. Future research should improve diagnostic tools, understand immunological mechanisms, and enhance prophylaxis. Early detection and treatment are key to better outcomes.</p>