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<p>Mitochondrial DNA copy number (mtDNA-CN) is a critical marker of mitochondrial health and plays a key role in cellular bioenergetics. Alterations in mtDNA-CN have been associated with aging, metabolic disorders and neurodegenerative diseases. Recent studies have revealed that various plant-derived extracts, as well as the secondary metabolites they produce, known as phytochemicals, can modulate mtDNA-CN through mechanisms including the regulation of mitochondrial biogenesis, oxidative stress, and mtDNA repair. This review examines plant-derived extracts and phytochemical compounds from a wide range of plant species- including <i>Ginkgo biloba</i>, <i>Crocus sativus</i>, Curcumin and many others- able to modulate mtDNA dynamics, scavenging oxygen free radicals and improving antioxidant defense systems.</p>

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Modulation of mitochondrial DNA copy number: therapeutic potential of phytochemicals and plant extracts—a comprehensive review

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月10日

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  • Maria Rosaria Perri,
  • Annamaria Cerantonio,
  • Maria Grazia Cipriani,
  • Ida Manna,
  • Anna Aureli,
  • Beatrice Marziani,
  • Francesco Andreozzi,
  • Gaia Chiara Mannino,
  • Elettra Mancuso,
  • Carolina Averta,
  • Giancarlo Statti,
  • Luigi Citrigno,
  • Davide Mainieri

摘要

Mitochondrial DNA copy number (mtDNA-CN) is a critical marker of mitochondrial health and plays a key role in cellular bioenergetics. Alterations in mtDNA-CN have been associated with aging, metabolic disorders and neurodegenerative diseases. Recent studies have revealed that various plant-derived extracts, as well as the secondary metabolites they produce, known as phytochemicals, can modulate mtDNA-CN through mechanisms including the regulation of mitochondrial biogenesis, oxidative stress, and mtDNA repair. This review examines plant-derived extracts and phytochemical compounds from a wide range of plant species- including Ginkgo biloba, Crocus sativus, Curcumin and many others- able to modulate mtDNA dynamics, scavenging oxygen free radicals and improving antioxidant defense systems.