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<p>Hyperlipidemia, characterized by aberrant lipid metabolism, constitutes a pivotal risk factor for cardiovascular diseases (CVDs) and contributes to various metabolic complications. Although conventional lipid-lowering agents are widely used, their long-term clinical application is frequently constrained by adverse side effects. Consequently, natural polysaccharides have attracted significant attention as promising therapeutic candidates due to their potent hypolipidemic effects and favorable safety profiles. This review systematically elucidates the underlying mechanisms by which natural polysaccharides ameliorate hyperlipidemia. Furthermore, the structure–activity relationships (SAR) are critically examined, with particular emphasis on how physicochemical properties such as molecular weight, monosaccharide composition, and chemical modifications modulate biological activity. Finally, current limitations and major bottlenecks in existing research are discussed, and future perspectives are proposed. Collectively, this review provides a reference for the development of novel polysaccharide-based therapeutics for the management of hyperlipidemia.</p>

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Mechanisms and structure–activity relationship of hypolipidemic effects of polysaccharides from natural resources: a review

  • 期刊论文

  • 发表日期：

    2026年3月18日

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  • Yao Wu,
  • Yuying Zhang,
  • Chuanming Gong,
  • Bichang Fan,
  • Shuying Li,
  • Jiayi Zhang,
  • Yuze Li,
  • Xiaomei Song,
  • Dongdong Zhang

摘要

Hyperlipidemia, characterized by aberrant lipid metabolism, constitutes a pivotal risk factor for cardiovascular diseases (CVDs) and contributes to various metabolic complications. Although conventional lipid-lowering agents are widely used, their long-term clinical application is frequently constrained by adverse side effects. Consequently, natural polysaccharides have attracted significant attention as promising therapeutic candidates due to their potent hypolipidemic effects and favorable safety profiles. This review systematically elucidates the underlying mechanisms by which natural polysaccharides ameliorate hyperlipidemia. Furthermore, the structure–activity relationships (SAR) are critically examined, with particular emphasis on how physicochemical properties such as molecular weight, monosaccharide composition, and chemical modifications modulate biological activity. Finally, current limitations and major bottlenecks in existing research are discussed, and future perspectives are proposed. Collectively, this review provides a reference for the development of novel polysaccharide-based therapeutics for the management of hyperlipidemia.