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<p>Three-dimensional cell culture systems mimic native tissues via cell-cell and cell-matrix interactions, enabling functional models for regenerative medicine and drug research. As current biomaterials lack the hierarchical complexity of the extracellular matrix (ECM), the Matrix Evolution Consortium develops bioinspired, dynamic matrices from recombinant proteins and synthetic polymers, supported by advanced processing, biosensors for real-time monitoring, and <i>in silico</i> modeling.</p>

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Hierarchisch strukturierte, bioinspirierte Matrizes für funktionale Gewebe

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Antonina Lavrentieva,
  • Miriam Frommer,
  • Selin Kara,
  • Katharina Nikutta,
  • Sophia Rudorf,
  • Meike Stiesch,
  • Marie Weinhart,
  • Cornelia Lee-Thedieck

摘要

Three-dimensional cell culture systems mimic native tissues via cell-cell and cell-matrix interactions, enabling functional models for regenerative medicine and drug research. As current biomaterials lack the hierarchical complexity of the extracellular matrix (ECM), the Matrix Evolution Consortium develops bioinspired, dynamic matrices from recombinant proteins and synthetic polymers, supported by advanced processing, biosensors for real-time monitoring, and in silico modeling.