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<p>Microbial fermentation processes commonly utilize sugars as the carbon source. With a growing world population and the inherent demand for food and feed, the field is urged to move towards alternative carbon sources. Methanol and ethylene glycol present potent so-called next-generation feedstocks, which do not directly compete with food and feed production. Exploiting the advantages of the often-neglected ethylene glycol over methanol, we were able to design and implement a synthetic pathway to produce dihydroxy butyric acid and threonine in <i>Escherichia coli</i>.</p>

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Wie nachhaltige Bioprodukte aus Ethylenglykol und Methanol entstehen

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Johannes Radde,
  • Alrik Titze,
  • Nadine Ihle,
  • Cláudio J. R. Frazão,
  • Thomas Walther

摘要

Microbial fermentation processes commonly utilize sugars as the carbon source. With a growing world population and the inherent demand for food and feed, the field is urged to move towards alternative carbon sources. Methanol and ethylene glycol present potent so-called next-generation feedstocks, which do not directly compete with food and feed production. Exploiting the advantages of the often-neglected ethylene glycol over methanol, we were able to design and implement a synthetic pathway to produce dihydroxy butyric acid and threonine in Escherichia coli.