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<p>Complex cell culture systems are increasingly being used to study host-pathogen interactions with high physiological relevance. In contrast to monolayer cultures, organoids, differentiated tissue models, and organ-on-chip platforms better reproduce tissue architecture and barrier function, key determinants of infection processes. While challenges remain, such as immune cell integration, ongoing methodological advances are expected to further enhance their robustness and translational impact.</p>

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Komplexe 3D-Modelle als Schlüssel der Infektionsforschung

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Christina Neser,
  • Maximiliane Wußmann,
  • Christian Lotz,
  • Florian Groeber-Becker,
  • Maria Steinke,
  • Daniela Zdzieblo,
  • Christina Popp

摘要

Complex cell culture systems are increasingly being used to study host-pathogen interactions with high physiological relevance. In contrast to monolayer cultures, organoids, differentiated tissue models, and organ-on-chip platforms better reproduce tissue architecture and barrier function, key determinants of infection processes. While challenges remain, such as immune cell integration, ongoing methodological advances are expected to further enhance their robustness and translational impact.