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<p>Adhesion (a)GPCRs integrate adhesion, mechanosensation and signaling within one polypeptide. Their long N-termini contain diverse adhesion modules and a GPCR autoproteolysis-inducing (GAIN) domain that autoproteolyzes into an N-terminal fragment and a C-terminal fragment with an intramolecular agonist (<i>Stachel</i>), a 7-transmembrane (TM) core and a long intracellular tail. Mechanical changes can expose the Stachel and activate the 7TM core, which then engages G proteins, arrestins or other receptors.</p>

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Domänenarchitektur als organisierendes Prinzip der Rezeptorsignalgebung

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Beatriz Blanco-Redondo,
  • Ines Liebscher

摘要

Adhesion (a)GPCRs integrate adhesion, mechanosensation and signaling within one polypeptide. Their long N-termini contain diverse adhesion modules and a GPCR autoproteolysis-inducing (GAIN) domain that autoproteolyzes into an N-terminal fragment and a C-terminal fragment with an intramolecular agonist (Stachel), a 7-transmembrane (TM) core and a long intracellular tail. Mechanical changes can expose the Stachel and activate the 7TM core, which then engages G proteins, arrestins or other receptors.