Scholarlink

<p>Admixture between incoming Neolithic early farmers (EF) and western hunter-gatherers (WHG) of Europe formed late farmers (LF) ∼ 6,200 years ago. Analysis of HLA genotypes from 135 Neolithic individuals reveal allele frequency shifts from EF to LF, likely due to WHG influx. Both groups had lower HLA diversity than today, suggesting reduced pathogen pressure at the time. Declining frequencies of HLA alleles linked to chronic inflammation since the Neolithic may reflect early mismatch diseases.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Unser immungenetisches Erbe aus der Steinzeit

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月16日

查看全文
  • Almut Nebel,
  • Ben Krause-Kyora

摘要

Admixture between incoming Neolithic early farmers (EF) and western hunter-gatherers (WHG) of Europe formed late farmers (LF) ∼ 6,200 years ago. Analysis of HLA genotypes from 135 Neolithic individuals reveal allele frequency shifts from EF to LF, likely due to WHG influx. Both groups had lower HLA diversity than today, suggesting reduced pathogen pressure at the time. Declining frequencies of HLA alleles linked to chronic inflammation since the Neolithic may reflect early mismatch diseases.