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<p>We present a robust method for global DNA methylation analysis based on complete acid hydrolysis and mass spectrometry. Unlike enzymatic approaches, it is independent of sequence context and shows high reproducibility. Application to sea lettuce <i>Ulva</i> revealed microbiome-dependent changes in DNA methylation, highlighting its potential for quantitative epigenetic studies.</p>

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Analyse von DNA-Methylierung von hypermethylierter DNA

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年5月16日

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  • Julia Sindlinger,
  • Nico Ueberschaar

摘要

We present a robust method for global DNA methylation analysis based on complete acid hydrolysis and mass spectrometry. Unlike enzymatic approaches, it is independent of sequence context and shows high reproducibility. Application to sea lettuce Ulva revealed microbiome-dependent changes in DNA methylation, highlighting its potential for quantitative epigenetic studies.