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<p>The <i>in vitro</i> Transgenic Rodent Assay (TGRA) using metabolically competent primary MutaMouse hepatocytes represents a novel method for detecting gene mutations. Combining this assay with next generation sequencing enables sensitive quantification and mechanistic characterization of induced mutations. The approach enhances predictivity toward <i>in vivo</i> outcomes and may support the reduction of animal testing.</p>

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Mutagenitätsprüfung mit dem in vitro-TGRA: von Frequenzen zu Signaturen

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月16日

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  • Alina Göpfert,
  • Naveed Honarvar,
  • Dorothee Funk-Weyer,
  • Robert Landsiedel

摘要

The in vitro Transgenic Rodent Assay (TGRA) using metabolically competent primary MutaMouse hepatocytes represents a novel method for detecting gene mutations. Combining this assay with next generation sequencing enables sensitive quantification and mechanistic characterization of induced mutations. The approach enhances predictivity toward in vivo outcomes and may support the reduction of animal testing.