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<p>Coronaviruses rely on their RNA-dependent RNA polymerase (RdRp) for replication, making RdRp a prime target for antiviral drugs. We investigated the inhibition of SARS-CoV-2 RdRp by the non-nucleoside inhibitor HeE1-2Tyr. Using cryo-EM and biochemical experiments, we show that HeE1-2Tyr binds to RdRp as a stack of three molecules and competes with RNA binding. HeE1-2Tyr binding is stabilized by a conserved arginine bracket, suggesting that HeE1-2Tyr is effective against various coronaviruses.</p>

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Coronavirus-Replikation: Inhibition durch HeE1-2Tyr

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月1日

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  • Christian Dienemann,
  • Michael Lidschreiber

摘要

Coronaviruses rely on their RNA-dependent RNA polymerase (RdRp) for replication, making RdRp a prime target for antiviral drugs. We investigated the inhibition of SARS-CoV-2 RdRp by the non-nucleoside inhibitor HeE1-2Tyr. Using cryo-EM and biochemical experiments, we show that HeE1-2Tyr binds to RdRp as a stack of three molecules and competes with RNA binding. HeE1-2Tyr binding is stabilized by a conserved arginine bracket, suggesting that HeE1-2Tyr is effective against various coronaviruses.