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<p>Cellular communication relies on precise protein trafficking, yet conventional microscopy lacks the resolution to visualize nanoscale structures. STED microscopy combined with CRISPR-Cas9 endogenous tagging using SNAP- and Halo-tags enables high-resolution imaging of protein dynamics in their native environment, revealing detailed organization of secretory compartments, endosomes, and immune signaling organization.</p>

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STED microcopy – illuminating the nanoscale organization of the cell

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月1日

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  • Gresy Bregu,
  • Pia Lazki-Hagenbach,
  • Francesca Bottanelli

摘要

Cellular communication relies on precise protein trafficking, yet conventional microscopy lacks the resolution to visualize nanoscale structures. STED microscopy combined with CRISPR-Cas9 endogenous tagging using SNAP- and Halo-tags enables high-resolution imaging of protein dynamics in their native environment, revealing detailed organization of secretory compartments, endosomes, and immune signaling organization.