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<p>Plant systems are emerging as sustainable platforms for producing recombinant therapeutic proteins. This review highlights the role of the plant secretory pathway – particularly the ER and Golgi – in protein folding and glycosylation. Engineering ER structure and targeting human glycosylation enzymes to specific Golgi compartments enhances protein quality. Plant-based systems offer scalable, low-cost alternatives with improved safety for biopharmaceutical production.</p>

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Pflanzen als Plattformen für die Herstellung therapeutischer Proteine

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月22日

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  • Verena Kriechbaumer,
  • Carmen Mata,
  • Alastair J. McGinness

摘要

Plant systems are emerging as sustainable platforms for producing recombinant therapeutic proteins. This review highlights the role of the plant secretory pathway – particularly the ER and Golgi – in protein folding and glycosylation. Engineering ER structure and targeting human glycosylation enzymes to specific Golgi compartments enhances protein quality. Plant-based systems offer scalable, low-cost alternatives with improved safety for biopharmaceutical production.