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<p>Lung organoids are 3D, self-organizing structures derived from epithelial progenitor cells that replicate key aspects of the human lung. They serve as models for research and drug discovery. Modern methods such as single-cell RNA sequencing elucidate cell differentiation pathways and cellular mechanisms. Comparing results with patient data enhances the relevance of the findings. Organoids provide an ethical alternative to animal experiments and are increasingly replacing animal studies.</p>

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Einzelzellanalysen von Lungenorganoiden in der translationalen Forschung

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月18日

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  • Felix Ritzmann,
  • Daniela Yildiz,
  • Christoph Beisswenger

摘要

Lung organoids are 3D, self-organizing structures derived from epithelial progenitor cells that replicate key aspects of the human lung. They serve as models for research and drug discovery. Modern methods such as single-cell RNA sequencing elucidate cell differentiation pathways and cellular mechanisms. Comparing results with patient data enhances the relevance of the findings. Organoids provide an ethical alternative to animal experiments and are increasingly replacing animal studies.