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<p>RNA modifications are key regulators of cellular processes, yet selectively introducing these modifications into target RNAs remains challenging. We developed “designer organelles” to perform highly selective, guide-RNA-driven pseudouridylation of mRNA in living cells. Circular guide RNAs further enhance modification efficiency and specificity. These orthogonal RNA editing organelles (OREOs) thus represent a versatile new approach to precise RNA modification, with promising applications from basic research to therapeutic interventions.</p>

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Selektive RNA-Modifizierung durch OREOs

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月18日

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  • Lukas Schartel,
  • Edward A. Lemke

摘要

RNA modifications are key regulators of cellular processes, yet selectively introducing these modifications into target RNAs remains challenging. We developed “designer organelles” to perform highly selective, guide-RNA-driven pseudouridylation of mRNA in living cells. Circular guide RNAs further enhance modification efficiency and specificity. These orthogonal RNA editing organelles (OREOs) thus represent a versatile new approach to precise RNA modification, with promising applications from basic research to therapeutic interventions.