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<p>Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and a systemic chronic inflammatory disease. It is caused by factors such as aging and environmental pollution, and characterized by a dysfunction of the epithelium and immune defense. Lung organoids allow us to investigate how aging and environmental stressors impair epithelial regeneration and promote inflammation. These models enable the discovery of novel mechanisms and therapies for COPD and its associated comorbidities.</p>

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Lungen-Organoide bringen neuen Schwung in die COPD-Forschung

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月18日

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  • Lili Rusznyak,
  • Roxana-Maria Wasnick,
  • Maja C. Funk

摘要

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide and a systemic chronic inflammatory disease. It is caused by factors such as aging and environmental pollution, and characterized by a dysfunction of the epithelium and immune defense. Lung organoids allow us to investigate how aging and environmental stressors impair epithelial regeneration and promote inflammation. These models enable the discovery of novel mechanisms and therapies for COPD and its associated comorbidities.