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<p>Thiamine (vitamin B<sub>1</sub>) is an essential coenzyme for central metabolic pathways. Metazoans, including humans, have to take up thiamine via the solute carriers SLC19A2 and SLC19A3, because they lost the ability to synthesize thiamine de novo. Perturbation of these transport systems has severe effects on human health. Here we discuss the molecular mechanisms of thiamine recognition, transport and inhibition based on recently available cryo-Electron Microscopy structures of SLC19A3.</p>

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Membrantransport von Thiamin im menschlichen Körper

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月8日

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  • Florian Gabriel,
  • Christian Löw

摘要

Thiamine (vitamin B1) is an essential coenzyme for central metabolic pathways. Metazoans, including humans, have to take up thiamine via the solute carriers SLC19A2 and SLC19A3, because they lost the ability to synthesize thiamine de novo. Perturbation of these transport systems has severe effects on human health. Here we discuss the molecular mechanisms of thiamine recognition, transport and inhibition based on recently available cryo-Electron Microscopy structures of SLC19A3.