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<p>Low transduction efficiencies limit the effectiveness of retroviral vectors in gene therapy. Self-assembling nanostructures, such as peptide nanofibrils (PNF) and peptide amphiphiles (PA), are powerful transduction enhancers that address this challenge. They are highly effective, versatile, and cost-efficient, with broad applicability across various cell types. Their ease of GMP-compliant production and seamless integration into CAR-T and CAR-NK cell manufacturing processes make them ideal tools for advancing gene therapy.</p>

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Peptidnanofibrillen als Transduktionsverstärker für die Gentherapie

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年5月8日

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  • Lena Rauch-Wirth,
  • Jan Münch

摘要

Low transduction efficiencies limit the effectiveness of retroviral vectors in gene therapy. Self-assembling nanostructures, such as peptide nanofibrils (PNF) and peptide amphiphiles (PA), are powerful transduction enhancers that address this challenge. They are highly effective, versatile, and cost-efficient, with broad applicability across various cell types. Their ease of GMP-compliant production and seamless integration into CAR-T and CAR-NK cell manufacturing processes make them ideal tools for advancing gene therapy.