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<p>The gut microbiome plays a crucial role in human health, but the molecular mechanisms underlying microbial interactions remain poorly understood. Activity-based protein profiling (ABPP) enables functional annotation of uncharacterized enzymes, particularly proteases, using chemical tools. Applying ABPP, <i>Bacteroides fragilis</i> Protease 1 (Bfp1) was identified as an activator of the human protease-activated receptor 2 (PAR<sub>2</sub>), modulating intestinal inflammation and barrier integrity.</p>

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Funktionelle Charakterisierung unbekannter Proteasen des Mikrobioms

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月21日

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  • Nayab Shakil,
  • Markus Lakemeyer

摘要

The gut microbiome plays a crucial role in human health, but the molecular mechanisms underlying microbial interactions remain poorly understood. Activity-based protein profiling (ABPP) enables functional annotation of uncharacterized enzymes, particularly proteases, using chemical tools. Applying ABPP, Bacteroides fragilis Protease 1 (Bfp1) was identified as an activator of the human protease-activated receptor 2 (PAR2), modulating intestinal inflammation and barrier integrity.