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<p>We aimed to establish a rat TR model to further investigate the mechanisms of right heart remodeling and organ damage induced by TR. Intervention group rats (<i>n</i> = 6) underwent coronary stent system implantation via transjugular approach. The control group (<i>n</i> = 6) underwent the same procedure, except for coronary stent implantation. All rats survived at 8 weeks follow-up postoperatively. TR occurred immediately after the implantation of coronary stent in the intervention group. The right ventricular fractional area change (FAC) decreased by 33.9% compared with baseline from 0.59 ± 0.11% to 0.39 ± 0.10% (<i>P</i> = 0.005) and the tricuspid annular plane systolic excursion (TAPSE) decreased by 36.8% from 2.42 ± 0.31&#xa0;mm to 1.53 ± 0.45&#xa0;mm at 8 weeks (<i>P</i> &lt; 0.001). This animal model would be suitable to further investigate the mechanisms of right ventricular remodeling and other organ damage associated with TR.</p>

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Transjugular Transcatheter Tricuspid Valve Implantation of Coronary Stent System for Creating a Rat Tricuspid Regurgitation Model

  • 期刊论文

  • 发表日期：

    2026年6月3日

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  • Xiaoping Ning,
  • Hongjie Xu,
  • Quangong Zhao,
  • Jiajun Pan,
  • Xiaohong Liu,
  • Jingyi Cao,
  • Qin Li,
  • Sufan Ding,
  • Chao Ye,
  • Keng Zhong,
  • Shangyi Yu,
  • Fanglin Lu,
  • Lin Han,
  • Zhiyun Xu,
  • Fan Qiao

摘要

We aimed to establish a rat TR model to further investigate the mechanisms of right heart remodeling and organ damage induced by TR. Intervention group rats (n = 6) underwent coronary stent system implantation via transjugular approach. The control group (n = 6) underwent the same procedure, except for coronary stent implantation. All rats survived at 8 weeks follow-up postoperatively. TR occurred immediately after the implantation of coronary stent in the intervention group. The right ventricular fractional area change (FAC) decreased by 33.9% compared with baseline from 0.59 ± 0.11% to 0.39 ± 0.10% (P = 0.005) and the tricuspid annular plane systolic excursion (TAPSE) decreased by 36.8% from 2.42 ± 0.31 mm to 1.53 ± 0.45 mm at 8 weeks (P < 0.001). This animal model would be suitable to further investigate the mechanisms of right ventricular remodeling and other organ damage associated with TR.