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<p>Translational models for obstructive coronary artery disease are lacking. We aimed to develop a porcine model for obstructive coronary stenosis induced by bioresorbable stent (BRS) implantation in hypercholesterolemic proprotein convertase subtilisin/kexin-9 (PCSK9) minipigs. Fifteen hypercholesterolemic PCSK9 minipigs were randomized to percutaneous coronary intervention with Magmaris, Absorb or Desolve BRS. Optical coherence tomography (OCT) scans were performed at baseline and 6-months followed by histology. Matched OCT analysis showed minimal lumen area decreased from 7.62 ± 1.54 mm<sup>2</sup> at baseline to 2.12 ± 0.92 mm<sup>2</sup> at follow-up in the Magmaris group, from 6.99 ± 1.49 mm<sup>2</sup> to 3.07 ± 1.52 mm<sup>2</sup> in the Absorb group, and from 6.05 ± 1.11 mm<sup>2</sup> to 2.65 ± 0.93 mm<sup>2</sup> in the Desolve group. Histologic examination revealed advanced human-like stenosis. BRS implantation in hypercholesterolemic PCSK9 minipigs induced human-like stenoses and may serve as a feasible preclinical model for obstructive coronary artery disease.</p> Graphical Abstract <p></p>

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Induced Human-like Coronary Stenosis in Hypercholesterolemic PCSK9 Minipigs

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年3月25日

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  • Jacob Nicolaisen,
  • Christian Frøsig Bo Poulsen,
  • Martin Mæng Bjørklund,
  • Martin Nors Skov,
  • Maiken Kudahl Larsen,
  • Troels Thim,
  • Jouke Dijkstra,
  • Jacob Fog Bentzon,
  • Evald Høj Christiansen,
  • Niels Ramsing Holm

摘要

Translational models for obstructive coronary artery disease are lacking. We aimed to develop a porcine model for obstructive coronary stenosis induced by bioresorbable stent (BRS) implantation in hypercholesterolemic proprotein convertase subtilisin/kexin-9 (PCSK9) minipigs. Fifteen hypercholesterolemic PCSK9 minipigs were randomized to percutaneous coronary intervention with Magmaris, Absorb or Desolve BRS. Optical coherence tomography (OCT) scans were performed at baseline and 6-months followed by histology. Matched OCT analysis showed minimal lumen area decreased from 7.62 ± 1.54 mm2 at baseline to 2.12 ± 0.92 mm2 at follow-up in the Magmaris group, from 6.99 ± 1.49 mm2 to 3.07 ± 1.52 mm2 in the Absorb group, and from 6.05 ± 1.11 mm2 to 2.65 ± 0.93 mm2 in the Desolve group. Histologic examination revealed advanced human-like stenosis. BRS implantation in hypercholesterolemic PCSK9 minipigs induced human-like stenoses and may serve as a feasible preclinical model for obstructive coronary artery disease.

Graphical Abstract