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<p>Vestibular hair cells (HCs) in the inner ear, crucial for balance and spatial orientation, are classified into type I and type II subtypes, but the mechanisms regulating their differentiation remain unclear. In this study, we examined the role of <i>Pou4f3</i>, an important transcription factor, in vestibular HC differentiation using <i>Pou4f3</i><sup>DTR/DTR</sup> (deficient) and <i>Pou4f3</i><sup>CreER/CreER</sup> (knockout) mouse models. In <i>Pou4f3</i>-deficient mice, the HC number decreased, and immature HCs failed to develop type I characteristics, indicating a developmental arrest. While type II HCs differentiated normally, <i>Pou4f3</i> deficiency disrupted HC bundle formation and cell polarity. Findings from knockout models further confirmed the essential role of <i>Pou4f3</i> in vestibular HC subtype specification. This study underscores the critical role of <i>Pou4f3</i> in determining vestibular HC subtypes and offers insights into potential strategies for restoring vestibular function through HC regeneration.</p>

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Pou4f3 Deficiency Obstructs the Subtype Differentiation of Vestibular Hair Cells

  • 期刊论文

  • 发表日期：

    2025年8月24日

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  • Qin Zhou,
  • Yikang Huang,
  • Wenli Ni,
  • Mingchuan Feng,
  • Lingjie Wu,
  • Chuijin Lai,
  • Yanping Zhang,
  • Wenyan Li,
  • Yan Chen

摘要

Vestibular hair cells (HCs) in the inner ear, crucial for balance and spatial orientation, are classified into type I and type II subtypes, but the mechanisms regulating their differentiation remain unclear. In this study, we examined the role of Pou4f3, an important transcription factor, in vestibular HC differentiation using Pou4f3DTR/DTR (deficient) and Pou4f3CreER/CreER (knockout) mouse models. In Pou4f3-deficient mice, the HC number decreased, and immature HCs failed to develop type I characteristics, indicating a developmental arrest. While type II HCs differentiated normally, Pou4f3 deficiency disrupted HC bundle formation and cell polarity. Findings from knockout models further confirmed the essential role of Pou4f3 in vestibular HC subtype specification. This study underscores the critical role of Pou4f3 in determining vestibular HC subtypes and offers insights into potential strategies for restoring vestibular function through HC regeneration.