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<p>Pancreatic resection is indicated for pancreatic metastasis from renal cell carcinoma, but its role in the management of non-renal pancreatic metastasis (NRPM) remains unclear. This study aims to investigate the survival outcomes of patients who underwent pancreatic resection for NRPM. Eligible articles were retrieved from PubMed, and a pooled data analysis was performed to identify factors potentially associated with overall survival (OS). The final population consisted of 289 patients. The primary tumors included sarcoma in 91 cases, colorectal cancer in 77, melanoma in 49, breast cancer in 28, thyroid cancer in 23, and lung cancer in 21. The overall 5-year OS rate was 41.7%, with the corresponding value of 39.5% for sarcoma, 42.5% for colorectal cancer, 40.7% for melanoma, 44.1% for breast cancer, 59.5% for thyroid cancer, and 28.9% for lung cancer. Multivariate analyses identified primary lung cancer (hazard ratio = 2.241 [1.104–4.551], <i>P</i> = 0.026) as the only significant poor prognostic factor. In conclusion, surgical resection of NRPM is warranted to achieve a greater chance of long-term survival in select patients, and survival benefit is highly dependent on the individual histologic type of the primary tumor.</p>

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A Pooled Retrospective Analysis of Survival Outcomes after Resection for Non-renal Pancreatic Metastasis

  • 期刊论文

  • 发表日期：

    2026年6月27日

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  • Youqing Huang,
  • Dianqi Li,
  • Yongwen Li,
  • Yanming Zhou

摘要

Pancreatic resection is indicated for pancreatic metastasis from renal cell carcinoma, but its role in the management of non-renal pancreatic metastasis (NRPM) remains unclear. This study aims to investigate the survival outcomes of patients who underwent pancreatic resection for NRPM. Eligible articles were retrieved from PubMed, and a pooled data analysis was performed to identify factors potentially associated with overall survival (OS). The final population consisted of 289 patients. The primary tumors included sarcoma in 91 cases, colorectal cancer in 77, melanoma in 49, breast cancer in 28, thyroid cancer in 23, and lung cancer in 21. The overall 5-year OS rate was 41.7%, with the corresponding value of 39.5% for sarcoma, 42.5% for colorectal cancer, 40.7% for melanoma, 44.1% for breast cancer, 59.5% for thyroid cancer, and 28.9% for lung cancer. Multivariate analyses identified primary lung cancer (hazard ratio = 2.241 [1.104–4.551], P = 0.026) as the only significant poor prognostic factor. In conclusion, surgical resection of NRPM is warranted to achieve a greater chance of long-term survival in select patients, and survival benefit is highly dependent on the individual histologic type of the primary tumor.