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<p>Primary cutaneous adnexal adenocarcinoma not otherwise specified (PCAANOS) is a rare malignant neoplasm derived from adnexal structures, often posing diagnostic challenges due to nonspecific morphology and immunohistochemical overlap with metastatic adenocarcinomas. We describe a case of PCAANOS and review key diagnostic considerations, including histopathology, immunohistochemistry, and radiologic evaluation, emphasizing the necessity of excluding cutaneous metastasis. PCAANOS commonly affects older adults and may recur or metastasize. Accurate diagnosis requires comprehensive evaluation. Therapeutic guidelines remain undefined; management typically involves complete surgical excision. Multidisciplinary management is essential given the rarity and therapeutic complexity of PCAANOS.</p>

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Primary Cutaneous Adnexal Adenocarcinoma NOS: An Ultra-Rare Malignancy with Complex Diagnostic Requirements

  • 期刊论文

  • 发表日期：

    2026年5月13日

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  • Ravisankar Palaniappan,
  • Ramya Natarajan,
  • Padma Priya Camalarajan,
  • Udayashankar Carounanidy

摘要

Primary cutaneous adnexal adenocarcinoma not otherwise specified (PCAANOS) is a rare malignant neoplasm derived from adnexal structures, often posing diagnostic challenges due to nonspecific morphology and immunohistochemical overlap with metastatic adenocarcinomas. We describe a case of PCAANOS and review key diagnostic considerations, including histopathology, immunohistochemistry, and radiologic evaluation, emphasizing the necessity of excluding cutaneous metastasis. PCAANOS commonly affects older adults and may recur or metastasize. Accurate diagnosis requires comprehensive evaluation. Therapeutic guidelines remain undefined; management typically involves complete surgical excision. Multidisciplinary management is essential given the rarity and therapeutic complexity of PCAANOS.