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<p>Meibomian gland carcinoma is a rare but highly aggressive malignant eyelid tumor, often masquerading as various benign ocular conditions, thereby delaying diagnosis and treatment. We report a case of a 58-year-old female with a history of excision of meibomian carcinoma of the upper eyelid, presenting with nodal recurrence. Although palliative radiotherapy and chemotherapy helped achieve partial regression, the disease later progressed with slowly enlarging nodal mass, infiltration into adjacent structures, necessitating radical neck dissection with reconstruction. Histopathology confirmed lobulated tumor with comedo necrosis. Meibomian carcinoma carries a significant risk of locoregional recurrence and metastasis, with poor prognosis in advanced disease. This case underscores the exceptional rarity of the disease and demonstrates the shift in therapeutic approach from palliative to curative intent to optimize oncological outcomes and reduce recurrence-related morbidity.</p>

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Meibomian Gland Carcinoma with Metachronous Regional Nodal Metastasis: a Case Report and Review of Literature

  • 期刊论文

  • 发表日期：

    2025年11月22日

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  • Ravisankar Palaniappan,
  • Padma Priya Camalarajan,
  • Aroun Kumar. N,
  • Ashwin Retnam,
  • Haripriya R

摘要

Meibomian gland carcinoma is a rare but highly aggressive malignant eyelid tumor, often masquerading as various benign ocular conditions, thereby delaying diagnosis and treatment. We report a case of a 58-year-old female with a history of excision of meibomian carcinoma of the upper eyelid, presenting with nodal recurrence. Although palliative radiotherapy and chemotherapy helped achieve partial regression, the disease later progressed with slowly enlarging nodal mass, infiltration into adjacent structures, necessitating radical neck dissection with reconstruction. Histopathology confirmed lobulated tumor with comedo necrosis. Meibomian carcinoma carries a significant risk of locoregional recurrence and metastasis, with poor prognosis in advanced disease. This case underscores the exceptional rarity of the disease and demonstrates the shift in therapeutic approach from palliative to curative intent to optimize oncological outcomes and reduce recurrence-related morbidity.